Both the Lyriq and Cayenne have child safety locks to prevent children from opening the rear doors. The Lyriq has power child safety locks, allowing the driver to activate and deactivate them from the driver's seat and to know when they're engaged. The Cayenne’s child locks have to be individually engaged at each rear door with a manual switch. The driver can’t know the status of the locks without opening the doors and checking them.
In the past twenty years hundreds of infants and young children have died after being left in vehicles, usually by accident. When turning the vehicle off, drivers of the Lyriq are reminded to check the back seat if they opened the rear door before starting out. The Cayenne doesn’t offer a back seat reminder.
The Lyriq’s optional driver alert monitor detects an inattentive driver then sounds a warning and suggests a break. According to the NHTSA, drivers who fall asleep cause about 100,000 crashes and 1500 deaths a year. The Cayenne doesn’t offer a driver alert monitor.
Both the Lyriq and the Cayenne have standard driver and passenger frontal airbags, front side-impact airbags, driver and front passenger knee airbags, side-impact head airbags, height adjustable front shoulder belts, four-wheel antilock brakes, traction control, electronic stability systems to prevent skidding, crash mitigating brakes, daytime running lights, lane departure warning systems, blind spot warning systems, rearview cameras and rear cross-path warning.

